Today Tapbots have released Tweetbot for Mac 2.0, a huge update to their Mac app. Tweetbot 2.0 has been completely redesigned with Yosemite in mind. Gone are the awkward remnants of pre-iOS 7 textures, and in their stead are the clean translucency of Yosemite. Tweetbot 2.0 has updated column views, allowing for easier column creating and deletion, and it looks absolutely gorgeous on a retina display. Tweetbot has maintained its powerful mute filters, and even added better sync so now even your filters are synced, making for a completely seamless transition from Mac to the iOS app.
Tweetbot 2 can be found in the Mac App store for $12 ( a nice price cut over the last version) and is a free update for existing Tweetbot for Mac users.